Advances in mitochondrial autophagy regulation of bone remodeling and the role of drug intervention

WANG Yiyuan; LIU Siyi; JIANG Honghui; PU Wen; LIU Canyan; XU Jiake

doi:10.16190/j.cnki.45-1211/r.2024.11.006

Journal of Guangxi Medical University > 2024 > 41(11): 1483-1490. > DOI: 10.16190/j.cnki.45-1211/r.2024.11.006

WANG Yiyuan, LIU Siyi, JIANG Honghui, PU Wen, LIU Canyan, XU Jiake. Advances in mitochondrial autophagy regulation of bone remodeling and the role of drug intervention[J]. Journal of Guangxi Medical University, 2024, 41(11): 1483-1490. DOI: 10.16190/j.cnki.45-1211/r.2024.11.006

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Advances in mitochondrial autophagy regulation of bone remodeling and the role of drug intervention

WANG Yiyuan^{1, 2},
LIU Siyi³,
JIANG Honghui^{1, 2},
PU Wen^{1, 2},
LIU Canyan⁴,
XU Jiake^{5, 6, ,}

1.
Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Guangxi Medical University, Nanning 530021, China
2.
Guangxi Key Laboratory of Regenerative Medicine, Research Centre for Regenerative Medicine, Guangxi Medical University, Nanning 530021, China
3.
Life Sciences Institute, Guangxi Medical University, Nanning 530021, China
4.
College of Pharmacy, Guangxi Medical University, Nanning 530021
5.
School of Biomedical Sciences, the University of Western Australia, Perth 6009, Australia
6.
Shenzhen Institute of Advanced Technology Chinese Academy of Sciences, Shenzhen 518005, China

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Received Date: September 10, 2024

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Abstract

Abstracts

Bone remodeling is a complex process that includes two mutually coordinated phases of bone resorption and bone formation, which plays an important role in preventing bone aging and increasing bone density. In recent years, studies have shown that mitochondrial autophagy (mitophagy) plays an important regulatory role in the process of bone resorption and bone formation. Mitochondrial autophagy is a special cellular clearance process that maintains normal mitochondrial function and metabolism by removing damaged mitochondria. With the in-depth understanding of the regulatory mechanisms of mitophagy, combined with the study of drug interventions, it is expected that more effective treatments will be developed to improve the quality of life of patients with orthopedic-related diseases such as osteoporosis. At the same time, it will also provide new perspectives and strategies for the prevention and treatment of orthopedic-related diseases.
- mitophagy;
- bone remodeling;
- pharmacological interventions;
- orthopedic-related diseases

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References (54)

References

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Advances in mitochondrial autophagy regulation of bone remodeling and the role of drug intervention

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