Jia Yifei, Yu Xiaoling, Hu Ji. Correlation of serum inflammatory factors with systemic lupus erythematosus disease activity, humoral immunity and its diagnostic value[J]. Journal of Guangxi Medical University, 2023, 40(9): 1522-1527. DOI: 10.16190/j.cnki.45-1211/r.2023.09.013
Citation: Jia Yifei, Yu Xiaoling, Hu Ji. Correlation of serum inflammatory factors with systemic lupus erythematosus disease activity, humoral immunity and its diagnostic value[J]. Journal of Guangxi Medical University, 2023, 40(9): 1522-1527. DOI: 10.16190/j.cnki.45-1211/r.2023.09.013

Correlation of serum inflammatory factors with systemic lupus erythematosus disease activity, humoral immunity and its diagnostic value

More Information
  • Received Date: July 10, 2023
  • Available Online: January 31, 2024
  • Objective:To analyze the correlation between serum inflammatory factors and disease activity and humoral immune function in patients with systemic lupus erythematosus (SLE), and to evaluate the diagnostic value of serum inflammatory factors in SLE.Methods:A total of 80 SLE patients admitted to Shanghai Tongren Hospital from May 2019 to December 2021 were selected as SLE group.According to the SLE disease activity score (SLEDAI), the patients were divided into active group and inactive group.Another 80 healthy subjects during the same period were selected as healthy group.The serum levels of interleukin-6(IL-6), interleukin-10(IL-10), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP) and interferon-γ (IFN-γ) were detected.The receiver operating characteristic (ROC) curve was drawn to analyze the diagnostic value of serum inflammatory factors for SLE.The correlation between serum inflammatory factors and immunoglobulin and SLEDAI score was analyzed by Pearson correlation.Results:Serum CRP, IL-6, IL-10, IFN-γ and TNF-α levels in the SLE group were higher than those in the healthy group and the levels of serum inflammatory factors, IgA, IgM and IgG in the active SLE group were higher than those in the inactive SLE group(all P< 0.001).The AUC of serum CRP, IL-6, IL-10, IFN-γ, TNF-α and their combination in the diagnosis of SLE were 0.719 (95% CI:0.624-0.815), 0.879 (95% CI: 0.816-0.943), 0.699(95% CI: 0.606-0.792), 0.852(95% CI:0.782-0.923), 0.816 (95% CI: 0.728-0.905) and 0.962 (95% CI: 0.931-0.992), respectively.The binary logistic regression analysis found that serum CRP, IL-6, IL-10, IFN-γ and TNF-α levels were risk factors for SLE (all P< 0.001).Pearson correlation showed that serum CRP, IL-6, IL-10, IFN-γ and TNF-α were positively correlated with IgA, IgM, IgG and SLEDAI scores (all P< 0.001).Conclusion:Serum levels of inflammatory factors in SLE patients increase, which is related to humoral immune function and disease activity, and combined detection can effectively diagnose the occurrence of SLE.
  • [1]
    GERGIANAKI I, BORTOLUZZI A, BERTSIAS G.Update on the epidemiology, risk factors, and disease outcomes of systemic lupus erythematosus[J].Best practice& research, 2018, 32(2):188-205.
    [2]
    CATALINA M D, OWEN K A, LABONTE A C, et al.The pathogenesis of systemic lupus erythematosus: Harnessing big data to understand the molecular basis of lupus[J].Journal of autoimmunity, 2020, 110:102359.
    [3]
    伍 伟, 何东初.系统性红斑狼疮患者血清血小板反应蛋白1 水平与病情严重程度的关系[J].中国医药导报, 2020, 17(2):93-96.

    WU W, HE D C.Relationship between serum thrombocytopretin 1 level and severity of systemic lupus erythematosus patients[J].China medical review, 2020, 17(2):93-96.
    [4]
    杜 宇, 赵佰桥, 张谊雯, 等.Th22细胞及血清IL-22水平与狼疮性肾炎患者疾病活动度评分的相关性[J].中国现代医学杂志, 2021, 31(22):28-32.

    DU Y, ZHAO B Q, ZHANG Y W, et al.Correlation of Th22 cells and serum IL-22 levels with disease activity score in patients with lupus nephritis[J].Chinese journal of modern medicine, 2019, 31(22):28-32.
    [5]
    刘 洋, 李 萍.外周血BDNF 水平及T 细胞上TrkB 表达与系统性红斑狼疮患者病情活动性关系研究[J].标记免疫分析与临床, 2020, 27(1):102-104.

    LIU Y, LI P.Relationship between BDNF level in peripheral blood and TrkB expression in T cells and disease activity in patients with systemic lupus erythematosus[J].Marker immunoassay and clinic, 2020, 27(1):102-104.
    [6]
    中华医学会风湿病学分会.系统性红斑狼疮诊断及治疗指南[J].中华风湿病学杂志, 2010, 14(5):342-346.

    RHEUMATOLOGY BRANCH OF CHINESE MEDICAL ASSOCIATION.Guidelines for diagnosis and treatment of systemic lupus erythematosus[J].Chinese journal of rheumatology, 2010, 14(5):342-346.
    [7]
    DU T, PANG H, DING F, et al.Reduction in SLEDAI is associated with improved arterial stiffness in systemic lupus erythematosus[J].Medicine, 2020, 99(47):e23184.
    [8]
    JOSEPH S, GEORGE N I, GREEN-KNOX B, et al.Epigenome-wide association study of peripheral blood mononuclear cells in systemic lupus erythematosus: Identifying DNA methylation signatures associated with interferon-related genes based on ethnicity and SLEDAI[J].Journal of autoimmunity, 2019, 96:147-157.
    [9]
    TOUMA Z, GLADMAN D D, ZANDY M, et al.Identifying a response for the systemic lupus erythematosus disease activity 2000 glucocorticoid index[J].Arthritis care& research, 2021, 73(9):1243-1249.
    [10]
    张 燕, 王 刚.免疫球蛋白G 在系统性红斑狼疮患者血清中的表达及其与患者发生肾功能损伤的相关性研究[J].检验医学与临床, 2022, 19(17):2373-2375.

    ZHANG Y, WANG G.The expression of immunoglobulin G in serum of patients with systemic lupus erythematosus and its correlation with renal function impairment[J].Laboratory medicine and clinic, 2022, 19(17):2373-2375.
    [11]
    田 玉, 杨玉淑, 丁 萌, 等.系统性红斑狼疮患者血清IL-2Rα, OAS1, DNase1L3与疾病活动度和早期肾损伤的关系研究[J].现代生物医学进展, 2022, 22(11): 2096-2099, 2065.

    TIAN Y, YANG Y S, DING M, et al.Relationship between serum IL-2Rα, OAS1, DNase1L3 and disease activity and early renal injury in patients with systemic lupus erythematosus[J].Advances in modern biomedicine, 2022, 22(11):2096-2099, 2065.
    [12]
    郭 娜, 张 葵, 吕明华, 等.系统性红斑狼疮患者调节性T 细胞CD305 表达降低且IL-10 分泌减少[J].细胞与分子免疫学杂志, 2021, 37(1):61-66.

    GUO N, ZHANG K, LV M H, et al.CD305 expression and IL-10 secretion of regulatory T cells decreased in patients with systemic lupus erythematosus[J].Journal of cellular and molecular immunology, 2021, 37(1):61-66.
    [13]
    罗春华, 李 鹏, 李乾元, 等.系统性红斑狼疮患者血清细胞因子水平的变化及临床意义[J].医学综述, 2020, 26(8):1641-1644, 1649.

    LUO C H, LI P, LI Q Y, et al.Changes of serum cytokine levels in patients with systemic lupus erythematosus and its clinical significance[J].Medical review, 2020, 26(8):1641-1644, 1649.
    [14]
    AWALIA A, NOTOPURO H, SOEROSO J.Association of polymorphisms in C-reactive protein (CRP) promoter-821 A> G, -390 C> A/T, and plasma interferon-α (IFN-α)with plasma CRP level in javanese systemic lupus erythematosus(SLE) patients[J].Acta medica Indonesiana, 2021, 53(3):261-267.
    [15]
    YULIASIH Y, RAHMAWATI L D, NISA’N, et al.The association of complements, TGF-β, and IL-6 with disease activity, renal damage, and hematological activity in patients with Naïve SLE[J].International journal of inflammation, 2022, 2022:7168935.
    [16]
    王 智, 丁华兵, 张永生.系统性红斑狼疮患者外周血调节性B细胞表达与预后的相关性[J].中国中西医结合皮肤性病学杂志, 2021, 20(2):186-189.

    WANG Z, DING H B, ZHANG Y S.Correlation between peripheral blood regulatory B cells expression and prognosis in patients with systemic lupus erythematosus[J].Chinese journal of dermatovenereology of integrated traditional and western medicine, 2021, 20(2):186-189.
    [17]
    GEGINAT J, VASCO M, GEROSA M, et al.IL-10 producing regulatory and helper T-cells in systemic lupus erythematosus[J].Seminars in immunology, 2019, 44:101330.
    [18]
    LIU W, ZHANG S, WANG J.IFN-γ, should not be ignored in SLE[J].Frontiers in immunology, 2022, 13:954706.
    [19]
    信 军, 康 乐, 张艺森, 等.系统性红斑狼疮患儿血清sCTLA4, TNF-α水平表达及其临床意义[J].实用医院临床杂志, 2019, 16(4):198-200.

    XIN J, KANG L, ZHANG Y S, et al.Expression of serum sCTLA4 and TNF-α in children with systemic lupus erythematosus and its clinical significance[J].Journal of practical hospital clinical, 2019, 16(4):198-200.
    [20]
    SAMY E, WAX S, HUARD B, et al.Targeting BAFF and APRIL in systemic lupus erythematosus and other antibody-associated diseases[J].International reviews of immunology, 2017, 36(1):3-19.

Catalog

    Article views (127) PDF downloads (1) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return