Correlation of serum inflammatory factors with systemic lupus erythematosus disease activity, humoral immunity and its diagnostic value

Objective:To analyze the correlation between serum inflammatory factors and disease activity and humoral immune function in patients with systemic lupus erythematosus (SLE), and to evaluate the diagnostic value of serum inflammatory factors in SLE.Methods:A total of 80 SLE patients admitted to Shanghai Tongren Hospital from May 2019 to December 2021 were selected as SLE group.According to the SLE disease activity score (SLEDAI), the patients were divided into active group and inactive group.Another 80 healthy subjects during the same period were selected as healthy group.The serum levels of interleukin-6(IL-6), interleukin-10(IL-10), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP) and interferon-γ (IFN-γ) were detected.The receiver operating characteristic (ROC) curve was drawn to analyze the diagnostic value of serum inflammatory factors for SLE.The correlation between serum inflammatory factors and immunoglobulin and SLEDAI score was analyzed by Pearson correlation.Results:Serum CRP, IL-6, IL-10, IFN-γ and TNF-α levels in the SLE group were higher than those in the healthy group and the levels of serum inflammatory factors, IgA, IgM and IgG in the active SLE group were higher than those in the inactive SLE group(all P< 0.001).The AUC of serum CRP, IL-6, IL-10, IFN-γ, TNF-α and their combination in the diagnosis of SLE were 0.719 (95% CI:0.624-0.815), 0.879 (95% CI: 0.816-0.943), 0.699(95% CI: 0.606-0.792), 0.852(95% CI:0.782-0.923), 0.816 (95% CI: 0.728-0.905) and 0.962 (95% CI: 0.931-0.992), respectively.The binary logistic regression analysis found that serum CRP, IL-6, IL-10, IFN-γ and TNF-α levels were risk factors for SLE (all P< 0.001).Pearson correlation showed that serum CRP, IL-6, IL-10, IFN-γ and TNF-α were positively correlated with IgA, IgM, IgG and SLEDAI scores (all P< 0.001).Conclusion:Serum levels of inflammatory factors in SLE patients increase, which is related to humoral immune function and disease activity, and combined detection can effectively diagnose the occurrence of SLE.