Relationship between serum peroxiredoxin 1 level and depressive symptoms and subjective stress in T2DM patients

Objective:To analyze the correlation between serum peroxiredoxin 1 (PRDX1) level and depressive symptoms and subjective stress in patients with type 2 diabetes mellitus(T2DM).Methods:A total of 256 T2DM patients from Yulin No.2 Hospital, Shaanxi Province from July 2019 to December 2021 were recruited and divided into depression symptom group(n=56)and non-depression symptom group(n=200)according to the depression score of Depression Anxiety Stress Scales-21 (DASS-21).Serum PRDX1 levels were detected by enzymelinked immunosorbent assay.The psychological state of patients was evaluated according to DASS-21.Perceived Stress Scale(PSS)was used to evaluate the subjective stress degree of patients.Results:According to the DASS-21 score, the serum PRDX1 levels in the depressive symptom group were significantly higher than those in the non-depressive symptom group (P< 0.05).The serum PRDX1 levels in all T2DM patients were 12.98±3.70 ng/mL, and the serum PRDX1 levels were positively correlated with the DASS-21 depression score and stress score(P< 0.05).According to the receiver operating characteristic curve analysis, the area under the curve of serum PRDX1 level in diagnosing T2DM complicated with depressive symptoms was 0.767(95%CI:0.699-0.835), and the sensitivity and specificity were 87.5% and 68.5%, respectively.Pearson correlation analysis and multiple linear regression analysis corrected for multiple interfering factors showed that serum PRDX1 level was positively correlated with PSS score in T2DM patients with depressive symptoms(P< 0.001), but not with PSS score in T2DM patients without depressive symptoms (r=0.076, P=0.283).In addition, serum PRDX1 levels were positively correlated with IL-6 and TNF-α levels in T2DM patients with depressive symptoms (P< 0.001).Conclusion:The serum PRDX1 levels have a good efficacy in the diagnosis of depression in T2DM patients, and for T2DM patients with depressive symptoms, the continuous increase of serum PRDX1 levels is related to the low-grade inflammatory reaction and the degree of subjective stress.