Analysis of risk behavior changes and influencing factors of HIV infection among drug users in Binyang county of Guangxi from 2018 to 2022

Objective: To analyze the trend of risk behavior changes and the influencing factors of human immunodeficiency virus (HIV) infection among drug users in Binyang county of Guangxi from 2018 to 2022.Methods: In accordance with the requirements of the National AIDS Sentinel Surveillance Program, study subjects were randomly selected at sentinel site in Binyang county, and questionnaires and antibody tests for HIV, syphilis and HCV were conducted.Multifactorial Logistic regression model was performed to analyze the influencing factors of HIV infection in drug users.Results: A total of 1, 615 drug users were surveyed from 2018 to 2022, and a majority of them were Han Chinese adult males.The knowledge awareness rate of AIDS in each year was 99.75%, 99.75%, 100.00%, 100.00%, and 100.00% respectively, with an overall knowledge awareness rate of 99.88%, showing a year-on-year increase (χ²_trend=43.77, P＜ 0.001).There was a decreasing trend in the proportions of injecting drugs in the last month (χ²_trend=63.72, P＜ 0.001), sharing needles with others (χ²_trend=7.04, P=0.008), and having sex after drug use in the last year (χ²_trend=44.06, P＜ 0.001).Additionally, there was a yearly increasing trend in the proportion of condom use at the most recent sex after drug use (χ²_trend=4.40, P=0.036), and the proportion of adherence to condom use at the most recent year of commercial sex (χ²_trend=98.30, P＜ 0.001).From 2018 to 2022, the overall positive rates of HIV, syphilis and HCV in drug users were 5.70%, 10.50%and 59.40%, respectively.Furthermore, multifactorial Logistic regression analysis showed that educational levels equal to or above middle school (OR=0.52, 95% CI: 0.29-0.91), single/divorced/widowed (OR=2.75, 95% CI: 1.70-4.44), needle sharing (OR=25.21, 95% CI: 10.69-59.42), and HCV infection (OR=2.78, 95% CI:1.70-4.44) were influencing factors for HIV infection in drug users (all P＜ 0.05).Conclusion: AIDS-related risk behaviors among the drug users in Binyang county show a significant downward trend, and targeting interventions for different characteristics of the drug users are the key strategies to curb AIDS transmission.