精神分裂症患者社会认知损害的研究进展

邓斐; 杨学智; 柳冬洋

doi:10.16190/j.cnki.45-1211/r.2023.10.003

精神分裂症患者社会认知损害的研究进展

邓斐^1, ,,
杨学智^2,3,
柳冬洋³

1. 上海交通大学附属上海市精神卫生中心, 上海 200030;
2. 南宁市第五人民医院, 南宁 530001;
3. 广西医科大学公共卫生学院, 南宁 530021

基金项目:

美国国立精神卫生研究所RO-1 项目（No.MH108385）；上海市精神卫生中心启航项目（No.2018-QH-06）；上海市精神卫生中心院级项目（No.2021-YJG05）

详细信息

通讯作者:
邓斐,E-mail:ziruofeier@hotmail.com

中图分类号: R749.3
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- 文章访问数: 113
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出版历程
- 收稿日期: 2023-05-11
- 网络出版日期: 2024-01-31
- 刊出日期: 2023-10-01

Research progress of social cognitive deficits in patients with schizophrenia

1. Shanghai Mental Health Center Affiliated to Shanghai Jiaotong University, Shanghai 200030, China;
2. The Fifth People's Hospital, Nanning 530001, China;
3. School of Public Health, Guangxi Medical University, Nanning 530021, China

摘要

摘要近20 年来，认知心理学家发现人类除了神经认知功能（包括记忆、注意力、问题解决等）外还具有相对独立的社会认知功能，社会认知全面参与了情绪感知、情绪调控、社会线索判断与感知等社会活动，对人类维持社会功能至关重要。既往研究通过量表评估、神经影像学等手段已经证实精神分裂症患者在各个社会认知子模块均存在损害，但对精神分裂症患者社会认知功能的损害机制及治疗方案仍然处于探索阶段，需要进一步加深研究有助于精神分裂症患者恢复社会认知功能的干预手段。
- 精神分裂症 /
- 社会认知 /
- 心智理论
Abstract In the most recent 20 years, cognitive psychologists have discovered that in addition to neurocogni-tive functions(including memory, attention, problem solving, etc.), human beings also possess relatively indepen-dent social cognitive functions.Social cognition plays a vital role in various social activities, including emotion perception, emotion regulation as well as judgment of social cues, and is essential for sustaining human social functions.Previous research using scale assessment or neuroimaging measures has confirmed that patients with schizophrenia show impairments across all the domains of social cognition, but the mechanisms of social cogni-tive deficits and effective treatment strategies are still in the exploratory stage.Further research is needed to ex-plore intervention methods to help schizophrenia patients regain their social cognitive functions.
- schizophrenia /
- social cognition /
- theory of mind

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参考文献(66)

[1]	PHILLIPS M R, ZHANG J X, SHI Q C, et al.Prevalence, treatment, and associated disability of mental disorders in four provinces in China during 2001-05:an epidemiologi-cal survey[J].Lancet, 2009, 373(9680):2041-2053.
[2]	MESHOLAM-GATELY R I, GIULIANO A J, GOFF K P, et al.Neurocognition in first-episode schizophrenia:a me-ta-analytic review[J].Neuropsychology, 2009, 23(3):315-336.
[3]	FETT A K J, VIECHTBAUER W, DOMINGUEZ M, et al.The relationship between neurocognition and social cogni-tion with functional outcomes in schizophrenia:a metaanalysis[J].Neuroscience&biobehavioral reviews, 2011, 35(3):573-588.
[4]	GREEN M F, HORAN W F, LEE J.Social cognition in schizophrenia[J].Nature reviews neuroscience, 2015, 16(10):620-631.
[5]	ADOLPHS R.Conceptual challenges and directions for social neuroscience[J].Neuron, 2010, 65(6):752-767.
[6]	GREEN M F, HORAN W P, LEE J.Nonsocial and social cognition in schizophrenia:Current evidence and future directions[J].World psychiatry:official journal of the world psychiatric association (WPA), 2019, 18(2):146-161.
[7]	LIEBERMAN M D.Social cognitive neuroscience:A re-view of core processes[J].Annual review psychology, 2007, 58:259-289.
[8]	PINKHAM A E, PENN D L, GREEN M F, et al.The so-cial cognition psychometric evaluation study:results of the expert survey and RAND panel[J].Schizophrenia bul-letin, 2014, 40(4):813-823.
[9]	SAXE R.Uniquely human social cognition[J].Current opinion in neurobiology, 2006, 16(2):235-239.
[10]	VUILLEUMIER P, POUROIS G.Distributed and interac-tive brain mechanisms during emotion face perception:ev-idence from functional neuroimaging[J].Neuropsycholo-gia, 2007, 45(1):174-194.
[11]	SABATINELLI D.Emotional perception:meta-analyses of face and natural scene processing[J].Neuroimage, 2011, 54(3):2524-2533.
[12]	CASTELLI L, CARRARO L, VALMORI A, et al.Social Perception in schizophrenia:evidence of reduced preju-diced attitudes among people with a diagnosis of schizo-phrenia[J].Frontier in psychology, 2021, 12:644488.
[13]	SAVIA G N, VELLA L, ATMSTRONG C C, et al.Defi-cits in domains of social cognition in schizophrenia:a me-ta-analysis of the empirical evidence[J].Schizophrenia bulletin, 2013, 39(5):979-992.
[14]	KOBER H.Functional grouping and cortical-subcortical interactions in emotion:a meta analysis of neuroimaging studies[J].Neuroimage, 2008, 42(2):998-1031.
[15]	SATPUTE A B, WILSON-MENDENHALL C D, KLECK-NER I P, et al.Emotional Experience.In Brain Mapping:An encyclopedic reference[C].Los angles:elsevier, 2015.
[16]	BUHLE J T.Cognitive reappraisal of emotion:a metaanalysis of human neuroimaging studies[J].Cerebral cor-tex, 2014, 24(11):2981-2990.
[17]	GREEN M F, HELLEMANN G, HORAN W P, et al.From perception to functional outcome in schizophrenia:modeling the role of ability and motivation[J].Archives of general psychiatry, 2012, 69(12):1216-1624.
[18]	LUO H G, ZHAO Y L, FAN F M, et al.A bottom-up mod-el of functional outcome in schizophrenia[J].Scientific re-ports, 2021, 11(1):7577.
[19]	DEHELEAN L, ROMOSAN A M, BUCATOS B O, et al.Social and neurocognitive deficits in remitted patients with schizophrenia, schizoaffective and bipolar disorder[J].Healthcare, 2021, 9(4):365.
[20]	ZITO M F, SUBOTNIK K L, VENTURA J, et al.Aware-ness of illness is associated with better social and nonso-cial cognition in recent-onset schizophrenia[J].Schizo-phrenia research, 2021, 231:51-53.
[21]	SCHWARZBOLD M L, KERN R S, NOVACEK D M, et al.Self-stigma in psychotic disorders:clinical, cogni-tive, and functional correlates in a diverse sample[J].Schizophrenia research, 2021, 228:145-150.
[22]	BELL M D, CORBERA S, JOHANNESEN J K, et al.So-cial cognitive impairments and negative symptoms in schizophrenia:are there subtypes with distinct functional correlates?[J].Schizophrenia bulletin, 2013, 39(3):186-196.
[23]	SEN M S, NEHRA R, GROVER S.Social cognition in pa-tients with first episode of psychosis in remission[J].Indi-an journal of psychiatry, 2020, 62(5):544-554.
[24]	DENG F, PHILLIPS M R, CAI B, et al.Comparison of so-cial cognition using ad adapted Chinese version of the reading the mind in the eyes test in drug-naïve and regu-larly medicated individuals with chronic schizophrenia and healthy controls in rural China[J].Psychological med-icine, 2021, 16:1-13.
[25]	PINKHAM A E, PENN D L, GREEN M F, et al.The so-cial cognition psychometric evaluation study:results of the expert survey and RAND panel[J].Schizophrenia bul-letin, 2014, 40(4):813-823.
[26]	PINKHAM A E, HARVEY P D, PENN D L.Social cogni-tion psychometric evaluation:results of the final valida-tion study[J].Schizophrenia bulletin, 2017, 44(4):737-748.
[27]	CASTELLI F, HAPPE F, FRITH U, et al.Movement and mind:a functional imaging study of perception and inter-pretation of complex intentional movement patterns[J].Neuroimage, 2000, 12(3):314-325.
[28]	CRUZ B F, OLIVEIRA A M, DEL-BEN C M, et al.Vali-dation of the Brazilian version of the hinting task and fa-cial emotion recognition test (FERT-100) in patients with schizophrenia[J].Dementia&neuropsychlologia, 2022, 16(3):300-308.
[29]	AYDIN O, LYSAKER P H, BALICI K, et al.Associations of oxytocin and vasopressin plasma levels with neurocog-nitive, social cognitive and meta cognitive function in schizophrenia[J].Psychiatry research, 2018, 270:1010-1016.
[30]	COUTURE S M, PENN D L, LOSH M, et al.Comparison of social cognitive functioning in schizophrenia and high functioning autism:more convergence than divergence[J].Psychological medicine, 2010, 40(4):569-579.
[31]	KERN R S, GREEN M F, FISKE A P, et al.Theory of mind deficits for processing counterfactual information in persons with chronic schizophrenia[J].Psychological med-icine, 2009, 39(4):645-654.
[32]	KEE K S, HORAN W P, SALOVEY P, et al.Emotional in-telligence in schizophrenia[J].Schizophrenia research, 2009, 107(1):61-68.
[33]	MCCLEERY A, LEE J, FISKE A P, et al.Longitudinal sta-bility of social cognition in schizophrenia:a 5-year followup of social perception and emotion processing[J].Schizo-phrenia research, 2016, 176(2-3):467-472.
[34]	EROL A, PUTGUL G, KOSGER F, et al.Facial emotion recognition in schizophrenia:the impact of gender[J].Psy-chiatry investigation, 2013, 10(1):69-74.
[35]	CHARENBOON T, PATUMANOND J.Social cognition in schizophrenia[J].Mental illness, 2017, 9(1):7054.
[36]	KITOKO G M B, MAURAGE P, MIEZI S M M, et al.In-ter-individual variability of social perception and social knowledge impairments among patients with schizophre-nia[J].Psychiatry research, 2020, 290:112951.
[37]	ATKINSON A P, ADOLPHS R.The neuropsychology of face perception:beyond simple dissociations and function-al selectivity[J].Philosophical transactions of the royal so-ciety B biological sciences, 2011, 366(1571):1726-1738.
[38]	HAXBY J V, HOFFMAN E A, GOBBINI M I.Human neural systems for face recognition and social communica-tion[J].Biological psychiatry, 2002, 51(1):59-67.
[39]	DELVECCHIO G, SUGRANYES G, FRANGOU S.Evi-dence of diagnostic specificity in the neural correlates of facial affect processing in bipolar disorder and schizophre-nia:a meta-analysis of functional imaging studies[J].Psy-chological medicine, 2013, 43(3):553-569.
[40]	LI H J, CHAN R C K, MCALOMAN G M, et al.Facial emotion processing in schizophrenia:a meta-analysis of functional neuroimaging data[J].Schizophrenia bulletin, 2010, 36(5):1029-1039.
[41]	TAYLOR S F, KANG J, BREGE I S, et al.Meta-analysis of functional neuroimaging studies of emotion perception and experience in schizophrenia[J].Biological psychiatry, 2012, 71(2):136-45.
[42]	CARRINGTON S J, BAILEY A J.Are there theory of mind regions in the brain?A review of the neuroimaging literature[J].Human brain mapping, 2009, 30(8):2313-2335.
[43]	SCHURZ M, RADUE J, AICHHORN M, et al.Fractionat-ing theory of mind:a meta-analysis of functional brain im-aging studies[J].Neuroscience and biobehavioral reviews, 2014, 42:9-34.
[44]	RUSSELL T A, RUBIA K, BULLMORE E T, et al.Ex-ploring the social brain in schizophrenia:left prefrontal underactivation during mental state attribution[J].The American journal of psychiatry, 2000, 157(12):2040-2042.
[45]	EACK S M, WOJTALIK J A, NEWHILL C E, et al.Pre-frontal cortical dysfunction during visual perspective-tak-ing in schizophrenia[J].Schizophrenia research, 2013, 150(2-3):491-497.
[46]	LEE J, QUINTANA J, NORI P, et al.FMRI biomarkers of social cognitive skills training in psychosis:extrinsic and intrinsic functional connectivity[J].PLoS one, 2019, 14(5):e0214303.
[47]	DODELL-FEDER D, TULLY L M, LINCOLN S H, et al.The neural basis of theory of mind and its relationship to social functioning and social anhedonia in individuals with schizophrenia[J].Neuroimage clinical, 2014, 4:154-163.
[48]	PATEL G H, ARKIN S C, RUIZ-BETANCOURT D, et al.Failure to engage the temporoparietal junction/posterior superior temporal sulcus predicts impaired naturalistic so-cial cognition in schizophrenia[J].Brain:a journal of neu-rology, 2021, 144(6):1898-1910.
[49]	MOLENBERGHS P, CUNNINGTON R, MATTINGLEY J B.Brain regions with mirror properties:a meta-analysis of 125 human fMRI studies[J].Neuroscience and biobe-havioral reviews, 2012, 36(1):341-349.
[50]	LAMM C, DECETY J, SINGER, T.Meta-analytic evi-dence for common and distinct neural networks associat-ed with directly experienced pain and empathy for pain[J].Neuroimage, 2011(54):2492-2502.
[51]	KRING A M, ELIS O.Emotion deficits in people with schizophrenia[J].Annual review of clinical psychology, 2013, 9:409-433.
[52]	GEE D G, KARLSGODT K H, VAN ERP T G M, et al.Altered age-related trajectories of amygdala-prefrontal cir-cuitry in adolescents at clinical high risk for psychosis:a preliminary study[J].Schizophrenia research, 2012, 134(1):1-9.
[53]	SLESSOR G, PHILLIPS L H, BULL R.Exploring the specificity of age-related differences in theory of mind tasks[J].Psychology and aging, 2007, 22(3):639-643.
[54]	PARDINI M, NICHELLI P F.Age-related decline in men-talizing skills across adult life span[J].Experimental ag-ing research, 2009, 35(1):98-106.
[55]	KIRKLAND R A, PETERSON E, BAKER C A, et al.Me-ta-analysis reveals adult female superiority in "Reading the Mind in the Eyes Test" [J].North American journal of psychology, 2013, 15(1):121-146.
[56]	STONE W S, CAI B, LIU X H, et al.Association between the duration of untreated psychosis and selective cogni-tive performance in community-dwelling individuals with chronic untreated schizophrenia in rural[J].JAMA psychi-atry, 2020, 77(11):1116-1126.
[57]	BRUNE M.Theory of mind and the role of IQ in chronic disorganized schizophrenia[J].Schizophrenia research, 2013, 60(1):57-64.
[58]	BORA E, SEHITOGLU G, ASLIER M, et al.Theory of mind and unawareness of illness in schizophrenia[J].Eu-ropean archives of psychiatry and clinical neuroscience, 2007, 257(2):104-111.
[59]	KUCHARSKA-PIETURA K, MORTIMER A.Can anti-psychotics improve social cognition in patients with schizophrenia[J].CNS drugs, 2013, 27(5):335-343.
[60]	PENN D L, KEEFE R S, DAVIS S M, et al.The effects of antipsychotic medications on emotion perception in pa-tients with chronic schizophrenia in the CATIE trial[J].Schizophrenia reseach, 2009, 115(1):17-23.
[61]	FISZDON J M, REDDY L F.Review of social cognitive treatments for psychosis[J].Clinical psychology review, 2012, 32(8):724-740.
[62]	HORAN W P, KERN R S, GREEN M F, et al.Social cog-nitive skills training for individuals with schizophrenia:emerging evidence[J].American journal of psychiatric re-habilitation, 2008, 11:205-252.
[63]	WU Y, WANG L, YU F Q, et al.Intermittent theta burst stimulation as an optimal treatment for schizophrenia risk decision:An ERSP study[J].frontiers in psychiatry, 2021, 12:594102.
[64]	GAINSFORD K, FITZGIBBON B, FITZGERALD P B, et al.Transforming treatments for schizophrenia:virtual reality, brain stimulation and social cognition[J].Psychiat-ric research, 2020, 288:112974.
[65]	HORAN W P, GREEN M F.Treatment of social cognition in schizophrenia:current status and future directions[J].Schizophrenia research, 2019, 203:3-11.
[66]	张逗玉,薄奇静,李薇娣,等.精神分裂症社会认知研究进展[J].临床精神医学杂志, 2022, 32(5):408-411. ZHANG D Y, BO Q J, LI W D, et al.Research progress of social cognition in schizophrenia[J].Journal of clinical psychiatry, 2022, 32(5):408-411.

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