Abstract: Quality standard research is a crucial component of the standardization and modernization of pharmaceuticals. It plays an essential role in new drug development, evaluation of existing drugs, market regulation, and particularly in quality control during pharmaceutical production and clinical application. The research and establishment of quality standards represent key and common technologies in the development and utilization of traditional Chinese medicine (TCM) and ethnomedicine. The secondary development of TCM and ethnomedicine, driven by improved quality standards, can provide technical support for quality re-evaluation, transforming resource advantages into industrial advantages and product advantages into market competitiveness, thereby promoting comprehensive quality upgrading of TCM and ethnomedicine products. This paper discusses the general framework and formulation of drug standards, analyzes the current status and existing problems of standard research on Zhuang and Yao medicines in Guangxi, and proposes key common technologies, research methods, and approaches, aiming to provide references for the development of the TCM and ethnomedicine industry in the region.