Abstract: Objective: To understand the trends and influencing factors of the late presentation rate of AIDS patients in Qinzhou City of Guangxi, so as to provide a basis for targeted policy-making. Methods: Information on reported HIV/AIDS cases in Qinzhou from 2006 to 2023 was collected from the National Basic Information System for AIDS Prevention and Control. Late presentation cases were judged based on the criteria of the Chinese Center for Disease Control and Prevention. The trend of late presentation rate across different periods was tested by chi-square test for trend, and the influencing factors of late presentation were analyzed by univariate chisquare tests and multivariate logistic regression. Results: The total late presentation rate in Qinzhou from 2006 to 2023 was 48.45%, and the late presentation rate showed a linear increasing trend across different time periods（χ²=91.905, P＜0.001）. Multivariate logistic regression analysis showed that the late presentation rate was lower in the following cases: females（OR: 0.601, 95% CI: 0.541-0.668）, married marital status（OR: 0.761, 95% CI: 0.678-0.854）, high school education or above（OR: 0.851, 95% CI: 0.729-0.994）, domestic workers/homemakers/the unemployed（OR: 0.834, 95% CI: 0.740-0.941）, workers（OR: 0.676, 95% CI: 0.517-0.885） and retired（OR: 0.655, 95% CI: 0.491-0.874）, having an HIV-positive spouse/regular sexual partner（OR: 0.765, 0.660-0.886）, transmission via homosexual contact（OR: 0.273, 95% CI: 0.076-0.983）, sampled from compulsory health check（OR: 0.160, 95% CI: 0.125-0.203）, and other sources（OR: 0.740, 95% CI: 0.646-0.848）. Individuals aged 30 years and above（30-39 years: OR: 2.020, 95% CI: 1.749-2.334; 40-49 years old: OR: 2.834, 95% CI: 2.425-3.312; ≥50 years old: OR: 2.338, 95% CI: 2.018-2.709）, sampled from hospital（OR: 1.460, 95% CI: 1.335-1.598） had a higher late presentation rate. Conclusion: The late presentation rate of AIDS cases in Qinzhou City is relatively high and shows a linear increasing trend. Corresponding population-based testing and intervention should be strengthened according to the influencing factors to reduce the late presentation rate.