Abstract: Objective: To explore the clinical value of the dynamic changes of procalcitonin（PCT） and Creactive protein（CRP） in predicting the short-term outcome of sepsis-associated acute kidney injury（SA-AKI）. Methods: The clinical data of 305 patients with SA-AKI admitted to the First Affiliated Hospital of Guangxi Medical University from September 2021 to December 2022 were retrospectively analyzed. According to the 28-day transition, patients were divided into death group and survival group; patients who survived were divided into non-recovery group and recovery group according to renal function. PCT and CRP values at different times were observed, and the correlation analysis, regression analysis, receiver operating characteristic（ROC） curve analysis, and net reclassification improvement（NRI） analysis were used to explore the correlation between the dynamic changes of PCT and CRP and short-term adverse prognosis in patients with SA-AKI. Results: A total of 305 patients with SA-AKI were included with no loss to follow-up. Among the patients, 115（37.7%） died. In the death group, PCT and CRP levels in the first week, as well as serum creatinine（Scr）, the levels of PCT, and CRP in week 2 and weeks 3-4, were higher than those in the survival group, while baseline levels of PCT and CRP were lower than those in the survival group. Among the 190 surviving patients, 55（28.9%） had no renal function recovery. In the non-recovery group, the levels of Scr, PCT, and CRP in week 2 and and weeks 3-4 were significantly higher than those in the recovery group（all P＜0.05）. Spearman correlation analysis showed that there was a positive correlation between AKI staging at admission and baseline CRP level（r=0.150, P=0.044）, and survival group hospitalization time was positively correlated with PCT levels at each time point, PCT decline rate, baseline CRP level and week 1 CRP level（r=0.775, 0.575, 0.433, 0.196, 0.557, 0.308, 0.257; all P＜0.05）. The proportional Cox regression analysis showed that for every 1% increase in PCT and CRP reduction rates, the mortality rate decreased by 3.9% and 23.9% respectively（P＜0.05）. The time-adjusted Cox regression analysis indicated that the mortality rates in high-SCR, PCT, and CRP groups were 1.518, 2.448, and 2.020 times higher than those in the low-SCR group, respectively（P＜0.001）. Logistic regression analysis revealed that for every 1% increase in PCT and CRP reduction rates, the risk of renal function non-recovery decreased by 62.0% and 25.3% respectively（P＜0.05）. The ROC curve showed that the areas under the curve（AUC） of PCT, CRP decline rates and their combination for predicting death were 0.919, 0.870 and 0.922, respectively; the AUC for predicting renal function nonrecovery was 0.691, 0.688 and 0.706, respectively（P＜0.05）. The NRI analysis revealed that, compared with the CRP reduction rate, the NRI values of the combination of PCT and CRP reduction rates for predicting death and renal function non-recovery were 131.349%（95% CI: 112.317-150.381） and 40.208%（95% CI: 13.413-67.003）, respectively. Conclusion: PCT and CRP levels are closely related to the death and renal prognosis of SA-AKI patients. Dynamic changes of PCT and CRP are important factors affecting the short-term adverse prognosis of SAAKI patients, and the combination of the two can improve the prediction efficiency.