Objective To explore the clinical value of thromboelastography (TEG) combined with conventional coagulation function tests in predicting the occurrence of venous thromboembolism (VTE) in patients undergoing perioperative gynecologic malignant tumor.

Methods A total of 203 patients with gynecologic malignant tumors who underwent surgery in the Guangxi Medical University Cancer Hospital, Nanning from January 2021 to January 2022 and met the inclusion criteria were selected. They were divided into a VTE group and a non-VTE group based on the occurrence of VTE after surgery. The differences in TEG and conventional coagulation function between the two groups were compared, and binary logistic regression analysis was used to identify the high-risk factors for perioperative VTE in these patients. Receiver operating characteristic (ROC) curve analysis was also conducted to evaluate the value of TEG combined with conventional coagulation function tests in predicting VTE occurrence.

Results A total of 203 patients underwent surgery for gynecologic malignant tumors, and 30 cases of VTE occurred postoperatively, with an incidence of VTE being 14.8%. Multivariate analysis showed that patient age, AT3, and FIB were independent influencing factors for the occurrence of VTE during the perioperative period (P < .05). The ROC curve showed that the combined prediction of conventional coagulation function, thromboelastography, and age for postoperative VTE in patients had an area under the ROC curve (AUC) of 0.744, which was higher than that of single-item predictions as well as the combined prediction of conventional coagulation function and thromboelastography, with statistically significant differences (P < .05). The AUC of the combination of the R value, FIB, and D-dimer values in predicting the occurrence of VTE in patients after gynecologic malignant tumor surgery was 0.664.

Conclusion The independent risk factors for the occurrence of VTE in patients undergoing gynecologic malignant tumor surgery during the perioperative period include patient age, AT3, FIB. The combination of age, conventional coagulation function, and thromboelastography can effectively predict the risk of VTE in gynecologic malignant tumor patients during the perioperative period.