Abstract: Bone remodeling is a complex process that includes two mutually coordinated phases of bone resorption and bone formation, which plays an important role in preventing bone aging and increasing bone density. In recent years, studies have shown that mitochondrial autophagy (mitophagy) plays an important regulatory role in the process of bone resorption and bone formation. Mitochondrial autophagy is a special cellular clearance process that maintains normal mitochondrial function and metabolism by removing damaged mitochondria. With the in-depth understanding of the regulatory mechanisms of mitophagy, combined with the study of drug interventions, it is expected that more effective treatments will be developed to improve the quality of life of patients with orthopedic-related diseases such as osteoporosis. At the same time, it will also provide new perspectives and strategies for the prevention and treatment of orthopedic-related diseases.