Abstract: Objective: To explore the social alienation and its influencing factors of social alienation in middleaged and young patients with schizophrenia (SZ) in remission stage, as well as their correlation with family intimacy level, sense of shame, and sense of life control. Methods: A total of 320 middle-aged and young SZ patients in remission were selected by convenience sampling from those reviewed at the outpatient department of the Second Affiliated Hospital of Xinxiang Medical University from January 2021 to April 2022. The patients’basic information, social alienation, life control ability, family intimacy level, and disease-related shame level were investigated using the general information survey form, general isolation scale, personal mastery scale, family cohesion scale, and disease shame scale. Multiple linear regression analysis was used to analyze the influencing factors of social alienation in middle-aged and young SZ patients in remission. Pearson correlation analysis was used to analyze the correlation between social alienation, sense of life control, sense of shame, and family intimacy level in middle-aged and young SZ patients during the remission period. Results: The results of multiple linear stepwise regression analysis showed that the number of hospitalizations within one year, sense of life control, sense of shame, and family intimacy level were the influencing factors of social alienation in middle-aged and young SZ patients in remission (t=4.614 to -4.553, P＜0.05). The sense of life control and family intimacy level were significantly negatively correlated with the total score and various dimensional indicators of social alienation in middle-aged and young SZ patients in remission (r=-0.341 to -0.018; -0.348 to -0.149; P＜0.05), while the sense of shame was significantly positively correlated with the total score and various dimensional indicators of social alienation in middle-aged and young SZ patients in remission (r=0.364 to 0.127, P＜0.05). Conclusion: The number of hospitalizations within one year, sense of shame, sense of life control, and family intimacy level are independent factors affecting the social alienation of middle-aged and young SZ patients in remission. The sense of life control and family intimacy level are significantly negatively correlated with social alienation of middle-aged and young SZ patients in remission. The sense of shame is significantly positively correlated with social alienation of middle-aged and young SZ patients in remission. Targeted interventions should be given to improve their social integration problems.