Abstract: Objective: To investigate the effect of lncRNA-Scarna10 (Scarna10) on resveratrol (RSV)-induced polarization of macrophages. Methods: M1 polarization model of RAW264.7 macrophages was established by LPS and treated with RSV for 24 hours. The study groups were divided into control group, LPS group and RSV+ LPS group. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to detect the expression of Scarna10, and western blotting and immunofluorescence were used to detect the expression of macrophage polarization markers (iNOS, Arg-1, CD206). RAW264.7 cells were divided into Si-NC group, LPS+Si-NC group, RSV+LPS+Si-NC group and RSV+LPS+Si-Scarna10 group after silencing Scarna10, and the expression of Scarna10 and macrophage polarization markers in each group after transfection was detected. Results: After LPS induction and resveratrol intervention, the protein expression level of iNOS, a M1 polarization marker, was elevated in the LPS group, the protein expression levels of Arg-1 and CD206, M2 polarization markers, were elevated, while the protein expression level of iNOS was decreased in the RSV+LPS group. At the same time, the expression level of Scarna10 in the RSV+LPS group was higher than that in the LPS group. After silencing Scarna10, compared with the RSV+LPS+Si-NC group, the expression level of Scarna10 and the protein expression levels of Arg-1 and CD206 in RSV+LPS+Si-Scarna10 group were decreased, and the protein expression level of iNOS was elevated. The differences among the above groups were statistically significant (all P＜0.05). Conclusion: The expression of Scarna10 is upregulated in M1 macrophages following RSV intervention, and silencing Scarna10 can reverse the RSV-induced promotion of M1-to-M2 macrophage polarization.