子宫内膜异位症相关生物标志物研究进展

Research progress on biomarkers related to endometriosis

  • 摘要: 子宫内膜异位症(EMs)其特征是子宫腔外存在子宫内膜样组织,是育龄期妇女常见的一种慢性良性易复发疾病,全球发病率约为 10%。由于该病是一种多因素疾病,发病机制未阐明,目前诊断金标准仍为腹腔镜病理检查,临床上缺少敏感且特异的生物标志物,寻找准确可靠、适用于临床的无创生物标志物是当前研究的热点和重点。本文对与EMs相关的糖类蛋白、转录组学、自身抗体生物标志物中最重要、最新颖的研究结果进行总结,为早期诊断、靶向治疗提供新的策略。

     

    Abstract: Endometriosis (EMs), characterized by the presence of endometrioid tissue outside the uterine cavity, is a common chronic benign recurrent disease in women of childbearing age, with a global incidence rate of about 10%. Due to its multifactorial nature and unclear pathogenesis, the current diagnostic gold standard for this disease is still laparoscopic pathology. There is a lack of sensitive and specific biomarkers in clinical practice. Finding accurate, reliable, and applicable non-invasive biomarkers is currently a hot topic and focus of research. This article summarizes the most important and novel research results of EMs-related glycoproteins, transcriptomics, and autoantibody biomarkers, and provides new strategies for early diagnosis and targeted therapy.

     

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