Abstract: Objective: To analyse the demography and spatial-temporal distribution characteristics of Human Im-munodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) among men who have sex with men(MSM) in Guigang City from 2007 to 2021 and provide evidence for the prevention and control of HIV/AIDS in Guigang City.Methods: The data on HIV/AIDS cases among MSM in Guigang City from 2007 to 2021 were col-lected from the China Information System for Disease Control and Prevention.Descriptive epidemiology was used to analyse the demographic characteristics and incidence, and ArcGIS10.7 software was used for spatial au-tocorrelation analysis.Results: A total of 338 AIDS cases were reported among MSM in Guigang City from 2007 to 2021.The number of newly reported MSM cases increased from 1 to 43 each year, and the constituent ratio in-creased from 0.16% to 5.26%, with a 32.90-fold increase over 15 years.The overall trend was upwards (χ²_trend=102.874, P< 0.001).Global autocorrelation analysis showed that there was spatial clustering (Moran's I=0.116, Z=2.096, P=0.036) and high clustering (G=0.000008, Z=4.196, P< 0.01) of HIV/AIDS cases among MSM in Guigang City.The hot spot analysis found that the“hot spot”area was mainly concentrated in the midwest, fol-lowed by the northeast township or street.Conclusion: The prevalence of AIDS among MSM in Guigang City is on the rise, and there are spatial clustering and hot spots.The prevention and control of HIV in hot spots should be focused on, and the intervention for MSM should be strengthened.