Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease mediated by autoantibodies, and affects various organs including skin, kidney, nervous system and blood system.Its pathogenesis involves dysregulation of multiple signaling pathways and immune cells.Rresearches have demonstrated that circular RNA(circRNA) can modulate signaling pathways such as PI3K/Akt/mTOR, JAK/STAT, TLR, Wnt and Notch, and mediate the activation of T and B lymphocytes, thereby affecting the pathogenesis of SLE.This review focuses on the role of circular RNA in these pathways and its potential association with the occurrence and development of SLE, which is essential for gaining a comprehensive understanding of its pathogenesis as well as providing novel insights and targets for diagnosis and treatment of the disease.