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    T2DM患者血清过氧化还原酶1水平与抑郁症状及主观应激间的关系

    Relationship between serum peroxiredoxin 1 level and depressive symptoms and subjective stress in T2DM patients

      摘要
    • 摘要: 目的：分析血清过氧化还原酶1（PRDX1）水平与2 型糖尿病（T2DM）患者抑郁症状及主观应激的相关性。方法：选择2019年7月至2021年12月陕西省榆林市第二医院的256例T2DM患者，根据抑郁—焦虑—压力量表-21（DASS-21）抑郁评分将患者分为抑郁症状组（n=56）及无抑郁症状组（n=200）。采用酶联免疫吸附法检测血清PRDX1水平。根据DASS-21评估患者心理状态。采用压力知觉量表（PSS）评估患者的主观应激程度。结果：根据DASS-21评分，抑郁症状组中血清PRDX1水平显著高于无抑郁症状组的患者（P< 0.05）；所有T2DM 患者血清PRDX1 水平为（12.98±3.70）ng/mL，且血清PRDX1 水平与DASS-21抑郁评分和压力评分均呈正相关关系（P< 0.05）；经受试者工作特征曲线分析，血清PRDX1水平诊断T2DM合并抑郁症状的曲线下面积为0.767（95%CI：0.699～0.835），灵敏性、特异性分别为87.5%、68.5%；经Pearson相关性分析和校正多种干扰因素的多元线性回归分析，血清PRDX1水平与有抑郁症状的T2DM患者PSS评分呈正相关关系（P< 0.001），但与无抑郁症状的患者PSS评分无相关关系（r=0.076，P=0.283）。此外，对于有抑郁症状的T2DM患者，血清PRDX1水平与IL-6、TNF-α水平亦呈正相关关系（P< 0.001）。结论：血清PRDX1水平对诊断T2DM患者是否合并抑郁症有良好的效能，且对于出现抑郁症状的T2DM患者，血清PRDX1水平持续增加与患者机体低度炎症反应以及主观应激程度有关。

       

      Abstract: Objective:To analyze the correlation between serum peroxiredoxin 1 (PRDX1) level and depressive symptoms and subjective stress in patients with type 2 diabetes mellitus(T2DM).Methods:A total of 256 T2DM patients from Yulin No.2 Hospital, Shaanxi Province from July 2019 to December 2021 were recruited and divided into depression symptom group(n=56)and non-depression symptom group(n=200)according to the depression score of Depression Anxiety Stress Scales-21 (DASS-21).Serum PRDX1 levels were detected by enzymelinked immunosorbent assay.The psychological state of patients was evaluated according to DASS-21.Perceived Stress Scale(PSS)was used to evaluate the subjective stress degree of patients.Results:According to the DASS-21 score, the serum PRDX1 levels in the depressive symptom group were significantly higher than those in the non-depressive symptom group (P< 0.05).The serum PRDX1 levels in all T2DM patients were 12.98±3.70 ng/mL, and the serum PRDX1 levels were positively correlated with the DASS-21 depression score and stress score(P< 0.05).According to the receiver operating characteristic curve analysis, the area under the curve of serum PRDX1 level in diagnosing T2DM complicated with depressive symptoms was 0.767(95%CI:0.699-0.835), and the sensitivity and specificity were 87.5% and 68.5%, respectively.Pearson correlation analysis and multiple linear regression analysis corrected for multiple interfering factors showed that serum PRDX1 level was positively correlated with PSS score in T2DM patients with depressive symptoms(P< 0.001), but not with PSS score in T2DM patients without depressive symptoms (r=0.076, P=0.283).In addition, serum PRDX1 levels were positively correlated with IL-6 and TNF-α levels in T2DM patients with depressive symptoms (P< 0.001).Conclusion:The serum PRDX1 levels have a good efficacy in the diagnosis of depression in T2DM patients, and for T2DM patients with depressive symptoms, the continuous increase of serum PRDX1 levels is related to the low-grade inflammatory reaction and the degree of subjective stress.

       

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