Abstract: With the development of economy and society in China, the change of fertility policy, the changing social ecological environment, and the increasing exposure to adverse events in early life, the situation of pregnancy diseases and adverse birth outcomes in China is still severe.According to Dohah theory, adverse events that occur in early life may affect the occurrence of various diseases in adulthood, and this effect may even last for several generations.The birth cohort is mainly recruited among women before or during pregnancy to involve participants.The maternal health during pregnancy and the short-and long-term health outcomes of offspring are followed up, so as to find a variety of factors affecting overall lifecycle health outcomes and test the etiological hypothesis.At present, there are many birth cohorts with considerable size in China, but most of them are mainly for Han population.China is a multiethnic country, and the occurrence of many diseases has the characteristics of regional and ethnic distribution.Zhuang nationality is the most populous ethnic minority in China.However, the large-scale epidemiological survey on Zhuang population is very limited, so it is difficult to systematically summarize the health characteristics of Zhuang population, maternal and child health, and to provide effective prevention and control measures for adverse health outcomes in Zhuang population.Therefore, it is necessary to establish a large-scale birth cohort of Zhuang population, systematically describing the health characteristics of Zhuang population, maternal and child health, and exploring the relationship between early life exposure during childbirth and short-and long-term health outcomes of pregnant women and their offspring, so as to provide important evidence for effectively reducing the risk of adverse health outcomes in Zhuang population, improving the quality of birth population, and promoting the health of women and children.This paper systematically introduces the construction background, process, major research progress, innovation and future prospects of Guangxi Zhuang Birth Cohort.