Abstract: Objective: To analyze the influencing factors of intraoperative acquired pressure injury (IAPI) in children undergoing liver transplantation and construct a risk prediction model.Methods: The clinical data of 1, 161 children who underwent liver transplantation in the liver surgery department of Renji Hospital, Shanghai Jiao Tong University from July 2018 to June 2021 were retrospectively studied.According to whether IAPI occurred or not, the children were divided into IAPI group and non-IAPI group.Univariate analysis was used to screen the influencing factors of IAPI in children undergoing liver transplantation and a binary logistic regression risk prediction model was constructed.Area under the receiver operating characteristic (ROC) curve and Hosmer-Lemeshow test were used to verify the predictive value and goodness of fit of the model.Results: Of the 1, 161 children undergoing liver transplantation, 68 developed IAPI (5.857%).Explosivity hepatic failure, inherited metabolic disease, operation time> 8h and preoperative serum total bilirubin were the risk factors for IAPI in children undergoing liver transplantation (P< 0.05), while the routine nursing measures in preoperative care combined with sanyrene and micro-mobility every 2 hours were protective factors (P< 0.05).The Hosmer-Lemeshow test to construct logistic regression model showed that χ²=3.079, P=0.929, the area under the curve of ROC was 0.748, the Youden index was 0.366, the sensitivity was 0.838, and the specificity was 0.538.Conclusion: This risk prediction model for IAPI in children undergoing liver transplantation has good performance.Therefore, targeted preventive measures can be implemented for children at different risk levels based on the predicted results in clinical practice.