Abstract: The relevant data of GLOBOCAN2020 suggest that colorectal cancer, gastric cancer and liver cancer account respectively for 10%, 5.6% and 4.7% of newly diagnosed malignant tumors globally in 2020.Traditional Chinese medicine has cognized and treated digestive system tumor for thousands of years, and believes that blood stasis, heat toxicity, and phlegm are the important factors for tumor formation.Xihuang pill is a famous prescription of traditional Chinese medicine to clear heat and promote blood circulation and detoxification.Currently, it is often combined with modern medical therapy to treat malignant tumors of digestive system.Clinical and laboratory studies have shown that Xihuang pill/capsule combined with chemotherapy, radiotherapy, interventional therapy and other methods can enhance the efficacy and reduce the toxicity in the treatment of digestive system tumors.This paper describes the clinical research and related laboratory research of Xihuang pill/capsule combined with modern medicine in the treatment of malignant tumors of digestive system, and provides reference for further research of Xihuang pill/capsule combined with modern medicine in the treatment of malignant tumors of digestive system.