Abstract: Chronic non-communicable diseases (CNCDs) are characterized by insidious onset, long duration, and persistent progression, with their etiology often involving dynamic developmental processes.They exhibit pleiotropy, robustness, and rewiring, forming an intertwined network of health status and disease processes within the human body.Therefore, in terms of research strategies, it is necessary to break away from reductionist static concept and shift towards the complexity concept of systems biology.By leveraging the advantages of multiomics technologies and emphasizing the integration concept, we should focus on the interactions among the genome, exposome, and phenome at multiple omics levels, unveiling the dynamic, pleiotropic, and adaptive network correlations across different stages and levels throughout the lifespan.The research perspective should shift from a "single disease" approach to "multi-disease" medicine, and from a "disease-oriented" approach to a "person-oriented" approach.Starting from a multidimensional, multilevel, and multi-time point causal network, the identification of key clusters of molecular biomarkers that play crucial roles in the occurrence and development of CNCDs has become a cutting-edge focus in etiological research on CNCDs.