Abstract: Heavy metal poisoning is one of the major public health problems worldwide, and treatment of such poisoning remains a big challenge for the medical community.The author has been engaged in the research on the treatment of manganese poisoning with sodium para-aminosalicylate (PAS-Na) since 1986, and the intervention mechanism of PAS-Na on hippocampal nerve inflammation in lead-exposed rats was derived from the study.Some valuable experience has been gained from occupational hygiene, clinical investigation(descriptive toxicology), and in vitro and in vivo toxicology(mechanotoxicology).The difference between PAS-Na and general metal complexing agents (such as CaNa₂-EDTA) is that PAS-Na can pass through the blood-brain barrier and produce complexing, promoting manganese and lead excretion.What’s more, PAS-Na has an anti-inflammatory effect.The author’s previous studies have shown that PAS-Na has a significant treatment effect on manganese poisoning.Additionally, it can restore or improve learning and memory impairment induced by lead in rats, which may be related to its ability to promote hippocampal lead excretion and its anti-inflammatory effect.This study may provide a scientific basis or a new idea for the treatment of toxic encephalopathy such as lead, mercury, copper and thallium, generating promising prospects for clinical applications.Therefore, it is believed that only by combining scientific research work with the practical needs of medicine can better research results be obtained and better clinical significance or application prospects be produced.