Abstract: Objective: To determine seven components in Ganshu capsules, namely, polydatin, neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, isochlorogenic acid A, isochlorogenic acid B, and isochlorogenic acid C based on quantitative analysis of multi-components by single-marker (QAMS).Methods: High perfor-mance liquid chromatography (HPLC) was used with a Phenomenex NX-C₁₈(250 mm×4.6 mm×5 μm) column, acetonitrile-water (0.2% formic acid solution) was as mobile phase with gradient elution at the flow rate of 1.00 mL/min, and the detection wavelengths were 328 nm.With polydatin as the internal reference, the relative correc-tion factor of this component and the other six components were established, the contents of each component were calculated, and the contents determined by the external standard method were compared to verify the feasi-bility of the established method.Results: The relative correction factor(RCF)of neochlorogenic acid, chlorogen-ic acid,cryptochlorogenic acid, isochlorogenic acid B, isochlorogenic acid A, isochlorogenic acid C was 1.192 2, 1.183 9, 1.278 9, 1.051 0, 0.994 7 and 0.994 5, respectively, and their relative retention time(RRT)was 0.304 2, 0.503 6, 0.551 3, 1.153 1, 1.193 1 and 1.277 1, respectively.The results calculated by QAMS method for 5 batch-es of samples were consistent with the results measured by external standard method (the relative error is-5%-5%).Conclusion: The QAMS method is simple with good stability, precision and repeatability, and can be used for quality control of Ganshu capsules.