Abstract: Objective: To explore the effect of non-sustained ventricular tachycardia (NSⅤT) on the long-term prognosis of heart failure with preserved ejection fraction(HFpEF).Methods: A total of 225 qualified HFpEF pa-tients from January 2017 to December 2020 were selected as the research objects, and general clinical data were collected.The patients underwent 24 h Holter monitoring three times before discharge, one week after discharge and two weeks after discharge to record the occurrence of NSⅤT, and were divided into non-NSⅤT group and NSⅤT group based on this.Prospective follow-up was performed in all patients.The endpoint event was all-cause death.Life table method was used to estimate the survival rate.Multivariate cox proportional hazards re-gression model was used to analyze the relationship between NSⅤT and all-cause death.Results: Of 215 HFpEF patients included in the analysis, 47 developed NSⅤT, with an incidence of 21.9%.There was a significant differ-ence in the survival curve between the NSⅤT-free group and the NSⅤT group (χ²=7.641,P=0.006).The survival rate of non-NSⅤT group was higher than that of NSⅤT group.Multivariate cox proportional hazards regression analysis showed that NSⅤT was an independent risk factor for death.Conclusion: There is a high incidence of NSⅤT in patients with HFpEF, and NSⅤT affects the long-term prognosis of patients, which has certain guiding significance for the risk stratification of HFpEF patients and the formulation of treatment strategies.